Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa

Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa

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Using a bioactivity-guided fractionation method, two coumarins: minumicrolineacetonide (1) and epimurpaniculol senecioate (2), were isolated from the leaves ofMurraya omphalocarpa Hayata (Rutaceae).Compound 1 had been previously synthesizedand was now isolated from natural sources for the first time, and compound 2, possessing anegative optical rotation Creepy Crawlers/new items value, is new.The structures and their stereochemistry were fullyelucidated on the basis of spectroscopic and X-ray crystallographic techniques.Bothcompounds 1 and 2 are active in Lunch Bag the antiplatelet aggregation assay.Interestingly, thepossible acetonide artifact 1 displayed significant antiplatelet aggregation induced not onlyby AA and collagen but also by platelet activating factor (PAF).